Comparison
Semaglutide vs. Tirzepatide vs. Retatrutide: The 2025 Comparison
10 min read3 peptides covered
Comprehensive comparison of the three leading weight loss peptides — effectiveness, side effects, and cost.
Which is better: Semaglutide, Tirzepatide, or Retatrutide?
Tirzepatide shows higher average weight loss than Semaglutide (18-22% vs 12-15%). Retatrutide may exceed both (24%+ in trials) but is not yet approved. Semaglutide has the longest track record. Choice depends on goals, access, cost, and individual response.